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Abstract
Two new guaianolide-type sesquiterpenoids chrysanthemulides K and L (1 and 2), together with six known analogues (3–8), were isolated from an CH2Cl2 extract of the aerial parts of Chrysanthemum indicum. The structures of new compounds 1 and 2 were established by extensive spectroscopic analysis, including UV, IR, MS, NMR and computational electronic circular dichroism (ECD) methods. Inhibitory effects of all compounds on nitric oxide production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 1–8 displayed NO production inhibitory activity with IC50 values ranged from 3.5 to 34.3 µM.
Disclosure statement
The authors declare that there is no conflict of interest.
Additional information
Funding
This research work was financially supported from the National Natural Science Foundation of China (82003606), Scientific and Technological Key Project in Henan Province (212102311093), Key Scientific Research Projects of Universities of Henan Province (21A360002), and Scientific Research Nursery Project (MP2020-29).