Cyclic hexadepsipeptides from the fermentation of Fusarium sp. DCJ-A and their cytotoxic activities

Abstract

Beauvercin H (1), a new cyclic hexadepsipeptide, and two known ones (2 and 3) were isolated from the EtOH extract of the solid culture of Fusarium sp. Their structures were elucidated by spectroscopic analysis, including extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds 1–3 were tested for their cytotoxic activities. The results showed that all isolated compounds exhibited cytotoxic activities against five human cancer cell lines with IC₅₀ values ranging from 1.379 to 13.12 μM.

Graphical Abstract

Keywords:

• Fusarium sp.
• cyclic hexadepsipeptides
• cytotoxic activities

Acknowledgments

This project was financially supported by the National Natural Science Foundation of China (No. 31860099 and 81860624), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (grant 202001AW070002 to M.Z.), the Yunnan Ten Thousand Talents Program (grant YNWR-QNBJ-2019-206 to M.Z.), and the Candidates of the Young and Middle Aged Academic Leaders of Yunnan Province (grant 2019HB016 to M.Z.).

Disclosure statement

No potential conflict of interest was reported by the authors.

Supporting information available

¹³C NMR, ¹H NMR, HSQC, HMBC, ¹H-¹H COSY, and ROESY spectra of 1, this material is available free of charge via the internet.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.