Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 25, 2023 - Issue 5
Submit an article Journal homepage
133
Views
0
CrossRef citations to date
0
Altmetric
Notes

One new furostane saponin from Allium ramosum and lipid accumulation inhibitory activity

Duong Thi Hai Yena Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi10072, VietnamView further author information
,
Hoang Thi Tuyet Lanb Faculty of Basic Sciences, University of Transport and Communications, Hanoi11512, VietnamView further author information
,
Bui Thi Mai Anhb Faculty of Basic Sciences, University of Transport and Communications, Hanoi11512, VietnamView further author information
,
Phan Van Kiema Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi10072, VietnamView further author information
,
Bui Huu Taia Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi10072, VietnamView further author information
,
Le Thi Huyenc Faculty of Chemistry, VNU University of Science, Hanoi11416, VietnamView further author information
,
Pham Hai Yena Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi10072, VietnamView further author information
,
Nguyen Xuan Nhiema Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi10072, VietnamCorrespondence[email protected]
View further author information
&
Nguyen Thi Maib Faculty of Basic Sciences, University of Transport and Communications, Hanoi11512, VietnamCorrespondence[email protected]
View further author information
 show all
Pages 510-517 | Received 07 Mar 2022, Accepted 03 Jul 2022, Published online: 25 Jul 2022
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A new furostane saponin, ramosaponin (1), and four known furostane saponins, protodioscin (2), dehydrotomatoside (3), (25 R)-26-O-(β-D-glucopyranosyl)-furost-5-ene-3β,22α,26-triol 3-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (4), and anguivioside A (5) were isolated from the methanol extract of Allium ramosum seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell line. As a result, compound 1 showed significant lipid accumulation inhibitory activity with an IC50 value of 64.32 ± 3.87 µM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number [104.01-2018.332].

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.