Abstract
Three new C19–diterpenoid alkaloids, nagarumines A–C (1–3), together two known alkaloids, deoxyaconitine (4) and N-deethyldeoxyaconitine (5), were isolated from the roots of Aconitum nagarum. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The in vivo pharmacological studies revealed that nagarumine C (3) possessed comparable antinociceptive activity (ED50 = 76.0 μmol/kg) with the positive control drugs aspirin and acetaminophen.
Graphical Abstract
![](/cms/asset/77a2dfd2-0ffb-4d88-a966-0e30104e36f1/ganp_a_2109148_uf0001_c.jpg)
Disclosure statement
No potential conflict of interest was reported by the authors.