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Abstract
Two new guaiacene-type sesquiterpenes 13α-dihydroixerin acid, ixerin acid and one new secoguaiacene-type sesquiterpene secoixerin Z, along with four known compounds, were separated from ethanol extract of Ixeris sonchifolia. The structures were determined based on the detailed spectroscopic and physicochemical methods. The cytotoxic activity of the isolates was tested against A549 cells. Among them, compound 3 exhibited potent cytotoxicity against A549 cells with the IC50 of 5.6 ± 0.9 µM.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
The study was financially supported by National Natural Science Foundation of China [Grant Nos. 81573592, 81673564, 82174007, 82174274], Key Research and Development Project of Heilongjiang province [Grant No. GZ20210125], China.