Two new compounds from Pergularia tomentosa growing wildly in Jordan

Abstract

Phytochemical investigation of the aerial parts and latex of Pergularia tomentosa from Jordan, utilizing column chromatography accompanied with NMR (1 & 2D), IR, UV, and HR-ESI-Mass spectroscopy have led to the isolation and characterization of two new compounds, pergularol (1) and 3-O-acetyl-28-hydroxytaraxasterol (2) for the first time along with other ten known compounds including linoleic acid (3), 3'-didehydroafroside (4), apigenin (5), β-sitosteryl glucoside (6), luteolin (7), apigenin 7-(6''-crotonoyl)glucoside (8), 3'-O-β-glucopyranosylcalotropin (9), apigenin-7-O-β-D-glycoside (10), pergularine A (11), taraxasterol (12). Compound (8) is isolated for the first time from Pergularia genus.

Graphical Abstract

Keywords:

• Pergularia tomentosa
• pergularol
• 3-O-acetyl-28-hydroxytaraxasterol
• cardenolide

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All 1D and 2D NMR, IR, and UV data are given in the supplementary material.