Abstract
An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible ring-opening mechanism of 6,19-epoxy bridge in compound 7 was first proposed and the structures of intermediates were supported by the LC-MS analysis of the reaction mixture.
Graphical Abstract
![](/cms/asset/7e8a035c-e06c-4198-b852-24ab2bfb8fbe/ganp_a_2144260_uf0001_c.jpg)
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Acknowledgments
The authors acknowledge Dr. Pei-Cheng Zhang and Yue-Xia Zhang for useful discussion and Dr. Yan Wu for assistance in the NMR.
Disclosure statement
No potential conflict of interest was reported by the authors.