A new oleanane-type triterpenoid saponin with α-glucosidase inhibitory activity from Camellia nitidissima

Abstract

A new oleanane-type triterpenoid saponin, 21β, 22α-di-O-angeloyl-15α, 16α, 28-trihydroxyolean-12-ene 3β-O-α-L-rhamnopyranosyl-(1→3)-α-D-xylopyranosyl-(1→3)-β-D-glucopyranoside (1), together with five known compounds (2-5), were isolated from Camellia nitidissima. Their structures were elucidated based on spectroscopic methods, including extensive NMR and MS spectra. Compound 1 showed potential inhibitory activity on α-glucosidase with the IC₅₀ values of 185.9 ± 44.5 µmol/L.

Graphical Abstract

Keywords:

• Camellia nitidissima
• theaceae
• triterpenoid saponin
• α-glucosidase

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [No. 81460119], and the Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi (2018glmcy012).