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Abstract
A chemical investigation of 95% ethanol extract from the stem and branch of Tripterygium wilfordii has resulted in the isolation and characterization of two new compounds, one neolignan (1) and one phenylalanine derivative (2), as well as four known compounds (3–6). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound 1 was defined by X-ray crystallographic analyses and electronic circular dichroism calculation. In addition, compounds 2 and 4–6 exhibited inhibitory effects against NO production in LPS-induced RAW 264.7 macrophages with the IC50 value ranging from 3.51 μM to 30.40 μM.
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Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This research work was financially supported by the grant [2020A1515010389] of Natural Science Foundation Committee of Guangdong Province, the National Key R&D Program of China [No. 2017YFC1703800], and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research [No. 2020B1212060076].