Two new compounds from the Hainan Soft Corals Sinularia tumulosa and Sinularia depressa with their anti-inflammatory or cytotoxic activities

Abstract

The detailed chemical investigations of the South China Sea soft corals Sinularia tumulosa and Sinularia depressa, yielded two new compounds, namely tumulosterol A (1) and 11’-hydroxy-α-tocopherylquinone (3), along with four related known ones (2, 5–7). Their structures were determined by extensive spectroscopic analysis and comparison with the spectral data previously reported in the literature. In bioassays, compound 1 displayed significant cytotoxic effects against H1975 and MDA-MB-231 cells with IC₅₀ values of 6.0 and 6.3 µM, respectively. In addition, compound 3 exhibited interesting inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells with IC₅₀ value of 9.5 µM.

Graphical Abstract

Keywords:

• Sinularia
• marine natural product
• anti-inflammatory activity
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China [No. 81991521], the SKLDR/SIMM Project [No. SIMM2103ZZ–06]. We thank Prof. X.-B. Li from Hainan University for the taxonomic identification of the soft coral materials.