Isolation and structure elucidation of antioxidant compounds from stem and root barks of Daphne giraldii

Abstract

Two new compounds, aphegiractin A₁/A₂ (1a/1b), and seven known compounds were isolated by phytochemical work on EtOAc-soluble ingredients extracted from stem and root barks of Daphne giraldii. Their structures were established based on extensive spectroscopic methods, including HRESIMS, CD experiments, 1D and 2D NMR. All compounds were evaluated for their antioxidant activity to DPPH, ABTS radical scavenging activity and inhibitory activity on tyrosinase. Of these compounds, compound 3 exhibited significant antioxidant activities.

Keywords:

• Thymelaeaceae
• Daphne giraldii
• coumarins
• antioxidant activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by National Nature Science Foundation of China [81673324], Liaoning province Natural Science Foundation of China [2020-MS-191], Support Plan for Young and Middle aged Innovative Talents of Shenyang [RC220386].