New abietane and tigliane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxic activities

Abstract

Three new abietane and two new tigliane diterpenoids were isolated from the roots Euphorbia fischeriana. Their structures were elucidated by spectroscopic methods and quantum chemical calculation. Compounds 4 and 5 exhibited the inhibitory activities against human cancer cells HeLa and HepG2, with IC₅₀ ranging from 3.54 to 11.45 µM.

Keywords:

• Euphorbia fischeriana
• abietane
• tigliane
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [Nos. 82073953, 81673530 and 82293680 (82293685)], and the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences [2021-RC350-009].