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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 11
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A new chromone from Kandelia candel endophytic fungus Aspergillus sp. ZJ-68

Wen-Bin LiuSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
,
Jing TangSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
,
Jia-Lin LiSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
,
Chen ChenSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
,
Li WuSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
,
Jun-Sen LiSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaView further author information
&
Yu-Hua LongSchool of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou510631, ChinaCorrespondence[email protected]
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Pages 1125-1131 | Received 10 Feb 2023, Accepted 27 Mar 2023, Published online: 12 Apr 2023
 
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Abstract

One chromone (1), together with four known alkaloids, were isolated from the mangrove endophytic fungus Aspergillus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound 1 showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 4.094 ± 0.8 μM, which was better than positive drug indomethacin (IC50=35.8 ± 0.5 μM).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors gratefully acknowledge the grants from National Natural Science Foundation of China [No. 41876153] and Guangdong Marine Economy Development Special Project [No. GDNRC[2022]35].

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