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Journal of Asian Natural Products Research Volume 26, 2024 - Issue 3
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Research Articles

Three new quinolizidine alkaloids from the roots of Sophora tonkinensis

Qiao Ana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, ChinaView further author information
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Ji Zhanga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang550025, ChinaView further author information
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Peng Zhanga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, ChinaView further author information
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Lei Chend Administrative Examination and Approval Service Center, People’s Government of Shijiazhuang, Shijiazhuang050601, ChinaView further author information
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Ping Yia State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, ChinaView further author information
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Chun-Mao Yuana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, ChinaView further author information
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Zhan-Xing Hua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, ChinaCorrespondence[email protected]
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Xiao-Jiang Haoa State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Natural Products Research Center of Guizhou Province, Guiyang550014, China;e State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650201, ChinaCorrespondence[email protected]
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Pages 302-312 | Received 06 Apr 2023, Accepted 01 Jun 2023, Published online: 13 Jun 2023
 
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Abstract

Three new quinolizidine alkaloids (1 − 3), including one new naturally isoflavone and cytisine polymer (3), along with 6 known ones were isolated from the ethanol extract of Sophora tonkinensis Gagnep. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, HRESIMS, 1D and 2D NMR), combined with ECD calculations. The antifungal activity against Phytophythora capsica, Botrytis cinerea, Gibberella zeae, and Alternaria alternata of the compounds was evaluated in a mycelial inhibition assay. Biological tests indicated that compound 3 exhibited strong antifungal activity against P. capsica with EC50 values of 17.7 μg/ml.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the Department of Science and Technology Department of Guizhou Province (QKH ZC-[2021]-YB181 and ZYD-[2022]-4015), the National Natural Science Foundation of China (U1812403 and 32160103).

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