Prenylated C₆–C₃ derivatives from the root of Illicium ternstroemioides with antiviral activity

Abstract

Six previously undescribed prenylated C₆-C₃ derivatives (1-6) were isolated from the root of Illicium ternstroemioides A. C. Smith. Their structures were elucidated based on extensive spectroscopic analyses (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of 1-3 were determined using electronic circular dichroism (ECD), and Mo₂(OAc)₄ induced circular dichroism (ICD). Compound 3 exhibited weak activity against Coxsackievirus B3 with an IC₅₀ value of 33.3 µM, and compound 5 exhibited more potent activity against Coxsackievirus B3 with an IC₅₀ value of 6.4 µM.

Keywords:

• Illiciaceae
• Illicium ternstroemioides A.C. Smith
• prenylated C₆-C₃ derivatives
• anti-Coxsackievirus

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [No: 22177135].