Four new alkaloids from the roots of Dactylicapnos scandens

Abstract

Four new alkaloids (1 − 4), together with five known ones (5 − 9), were isolated from the bulbs of Dactylicapnos scandens. The structures were determined by analysis of their spectroscopic data and quantum-chemical calculations. All the isolates were tested for their ability to modulate neuronal Ca²⁺ mobilization in primary cultured neocortical neurons. Compound 8 inhibited spontaneous Ca²⁺ oscillations at low micromolar concentrations.

Keywords:

• Papaveraceae
• Dactylicapnos scandens
• alkaloid
• Ca²⁺ oscillations

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NO. 81872974); the Fundamental Research Funds for the Central Universities (NO. 2632023TD02) and the Open Project of State Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources (NO. CMEMR2023-B01).