Abstract
Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (4′-O-MG DHRSV, 1) and 3-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (3-O-MG DHRSV, 2) on the basis of spectroscopic methods. They showed moderate SIRT3 agonistic activity, and compound 2 exhibited the best deacetylation of 406.63% at 10 μM. The activity of 2 increased by 3.12-fold compared with that of DHRSV, since 2 performed better in molecular docking assay (GScore −8.445).
Acknowledgements
We are grateful to the Department of Instrumental Analysis of our institute for measurement of the IR, NMR, and HRESIMS data. We acknowledge Topscience for providing molecular docking services.
Disclosure statement
No potential conflict of interest was reported by the author(s).