Phenolic and flavonoid compounds from the fruit shell of Camellia oleifera

Abstract

A new phenolic compound oleiphenol (1), and a new dihydrochalcone oleifechalcone (2) along with seven known compounds (3-9) were isolated from the fruit shell of Camellia oleifera Abel. The planar structures of compounds 1 and 2 were determined on the basis of extensive spectroscopic analyses (IR, UV, NMR, and HR-ESI-MS) and comparison with literature data. The absolute configurations of the new structures were determined by ECD calculations and chemical methods. In addition, compounds 1-9 underwent a series of pharmacological activity tests, including cytotoxic, anti-inflammatory, anti-RSV and antioxidant activities.

Keywords:

• Camellia oleifera
• cytotoxic
• anti-inflammatory
• anti-RSV
• antioxidant
• fruit shell

Authors’ contributions

In this work, Qing Shu designed the experiments and the manuscript writing; Yu-Jun Tang and Yi-Xia Liu performed the pharmacological activity assay, Huai-Yu Chen, Ya-Yu Wu performed the extraction, isolation; Wei Xu carried out the structural elucidations; Yu-Bo Zhang and Guang-Xiong Zhou decided the research subject and reviewed the manuscript.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

We gratefully acknowledge support from the grant (32220053) of Natural Science Foundation Committee of Guangdong Province, and the National Key R&D Program of China (No. 2017YFC1703800).