Progress of studies on natural products for glioblastoma therapy

Abstract

Glioblastoma (GBM) is the most common, malignant, and lethal primary brain tumor in adults. Up to now, the chemotherapy approaches for GBM are limited. Therefore, more studies on identifying and exploring new chemotherapy drugs or strategies overcome the GBM are essential. Natural products are an important source of drugs against various human diseases including cancers. With the better understanding of the molecular etiology of GBM, the development of new anti-GBM drugs has been increasing. Here, we summarized recent researches of natural products for the GBM therapy and their potential mechanisms in details, which will provide new ideas for the research on natural products and promote developing drugs from nature products for GBM therapy.

Keywords:

• Glioblastoma/glioma
• medications
• natural products
• anticancer

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Beijing Natural Science Foundation (7212157, China). This work was also supported by CAMS Innovation Fund for Medical Sciences (2021-I2M-1-029, China) and (2021-I2M-1-028, China), National Natural Science Foundation of China (81703536 and 22278443, China), and International Cooperation Project of Qinghai Province (2020-HZ-803, China).