Two new sesquiterpenoid glycoside compounds from the calyces of Physalis alkekengi L. var. franchetii (Mast.) Makino

Abstract

Two new sesquiterpenoid glycosides, 8α (H)-eudesmane-1,3,11 (13)-triene-2-one -12-O-β-D-glucopyranoside (1) and dmetelisproside B (2), together with ten known compounds (3–12) were isolated from calyces of Physalis alkekengi L. var. franchetii (Mast.) Makino (PAF). Their structures were unambiguously elucidated through HR-ESI-MS, UV, IR, and NMR spectral data. Compounds 1, 10, and 12 exhibited DPPH scavenging ability with IC₅₀ values of 33.69 ± 6.65, 6.29 ± 0.06, and 25.66 ± 3.06 μM, respectively. Additionally, 10 and 12 demonstrated weak α-glucosidase inhibition activity with IC₅₀ values of 250.9 ± 6.60 and 347.6 ± 2.48 μM, respectively.

Keywords:

• Solanaceae
• Physalis alkekengi L. var. franchetii (Mast.) Makino
• sesquiterpenoid glycoside
• antioxidant activity
• hypoglycemic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Natural Science Foundation of Heilongjiang Province (NO. YQ2019B008), Basic Scientific Research Foundation of the Higher Education Institutions of Heilongjiang Province, China (NO. 2022KYYWF0633), Heilongjiang Province Postdoctoral Science Foundation, China (NO. LBHZ20202) and North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province (No. HLJTSXK-2022-03).