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Journal of Asian Natural Products Research Volume 26, 2024 - Issue 7
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Research Articles

Synthesis, characterization and in vitro antiproliferative effects of isosteviol derivatives

Xin-Xin Qia School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian116029, ChinaView further author information
,
Pan-Pan Wanga School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian116029, ChinaView further author information
,
Lan-Tian Cuib Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji133002, ChinaView further author information
,
Mei Jinb Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji133002, ChinaView further author information
,
Long-Xuan Zhaoa School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian116029, ChinaCorrespondence[email protected]
View further author information
&
Gao Lib Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji133002, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1722-8859View further author information
ORCID Icon
Pages 812-823 | Received 25 Apr 2023, Accepted 01 Dec 2023, Published online: 13 Mar 2024
 
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Abstract

Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells in vitro. Among them, the inhibitory effect of compounds 3b and 16 on Hela cells was comparable to that of the positive control gefitinib, and the compounds 3b (IC50=7.84 ± 0.84 μM) and 7a (IC50=6.89 ± 0.33 μM) exhibited significant cytotoxicity superior to gefitinib (IC50=11.02 ± 3.27 μM) against A549 cells.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University(No. 602023004)and the National Natural Science Foundation of China (No. 82260834).

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