https://orcid.org/0000-0001-6367-8431
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Abstract
Two new cucurbitane-type triterpenoid saponins, 2,20β,22β-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-β-D-glucopyranoside (1), 2,20β,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-β-D-glucopyranoside (2) were isolated from the fruit of Citrullus colocynthis (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 μM against paracetamol-induced HepG2 cell damage.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This research was financially supported by Fundamental Research Funds for the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (No.2021-I2M-1-028), and Scientific and technological development plan project of Silk Road Economic Belt innovation driven development pilot zone and Wu Chang Shi national independent innovation demonstration zone (2023LQ01002-01).