A new phenanthrene with a spirolactone ring from Dendrobium ochreatum

Abstract

Dendroochreatene (1), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole Dendrobium ochreatum plant together with 11 known compounds (2–12). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from D. ochreatum. Moscatilin (4), major compound isolated from D. ochreatum, was found to be cytotoxic toward H460 lung-cancer cells, with an IC₅₀ value of 147.3 ± 0.9 µM, while loddigesiinol C (7), C-α-methoxy derivative was inactive.

Keywords:

• Dendrobium ochreatum
• Orchidaceae
• dendroochreatene
• phenanthrene
• spirolactone
• lung cancer

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

M.T.T. and C.P. are grateful to Chulalongkorn University for support from the Second Century Fund (C2F), which provided a postdoctoral fellowship for M.T.T. and a Ph.D. scholarship for C.P., both under the supervision of B.S.