Abstract
This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream’s potential as a topical treatment for burn wounds.
Acknowledgements
They are also thankful to Shri JJT University, Jhunjhunu, Rajasthan, for providing the necessary facilities and support to carry out this research project. The authors are also grateful to Dr. Avijit Choudhury, and Mr. Vishal Patel for their valuable support in carrying out the research work at Pretox Research Centre, Surat Gujarat.
Author contributions
STS identified the test formulation, generated resources, and did the in-vivo study execution and data analysis. AK supervised the project and gave final approval for the manuscript, SAA and DK performed the in-vitro experiments and manuscript reviewing. STS and DK prepared the formulation. SKD revised the overall manuscript. STS, AK, SAA, and SKD contributed to the final manuscript revision. AK and SKD supervised overall research project planning, generated resources, reviewed, and finally approved the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.