Mechanisms and therapeutic potential of chinonin in nervous system diseases

Abstract

The flavonoid compound chinonin is one of the main active components of Rhizoma anemarrhena with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. “Chinonin” OR “Mangiferin” AND “Nervous system diseases” OR “Neuroprotection” was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT author contributions

Conceived the review: HZ, JML. Wrote the review: HZ, LFW and XQW. Revised the review: BSH, LD. All of the authors reviewed the manuscript and approved it for publication.

Data availability statement

The data will be made available upon request.

Additional information

Funding

The Natural Science Foundation of Hunan Province [2023JJ30092]. The “14th Five-Year Plan” Application Characteristic Discipline of Hunan Province (Clinical Medicine), the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, and the Foundation of the Education Department of Hunan Province [22A0662], China. The Research Foundation of Education Bureau of Hunan Province [22C0673]. The first batch of ESI Discipline Construction Projects of Changsha Medical University in 2022 [2022CYY013].