Two new metabolites from the mangrove endophytic fungus No. 2524

Abstract

Two new metabolites, the cyclo-(l-Phe-l-Leu¹-l-Leu²-l-Leu³-l-Ile) (1) and (3S,4R)-dihydroxy-(6S)-undecyl-α-pyranone (2) have been produced by the endophytic fungus no. 2524 isolated from a seed of mangrove Avicennia marina in Hong Kong. The structures have been elucidated by spectra including two-dimensional NMR, ESI tandem mass spectrometry and CD. These compounds show no activity toward human cancer cell lines Bel-7402, NCI-4460 and the normal human cell lines L-02.

Keywords:

• Avicennia marina
• Endophytic fungus
• Metabolites
• Cyclo-(l-Phe-l-Leu1-l-Leu2-l-Leu3-l-Ile)
• (3S,4R)-Dihydroxy-(6S)-undecyl-α-pyranone

Acknowledgements

This work was supported by the 863-Foundation of China (2001AA624010), the National Natural Science Foundation of China (29672053), the Natural Science Foundation of Guangdong Province, China (021732) and the Research Foundation of Zhongshan University (31110-1131037).