Stilbenoids from the lianas of Gnetum pendulum

Abstract

The first new isorhapontigenin dimer glucoside gnetupendin D (1) and a stilbene dimer coupled by a resveratrol and an oxyresveratrol with a cis-dihydrobenzofuran were obtained from the lianas of Gnetum pendulum C. Y. Cheng (Gnetaceae), along with nine known compounds. Their structures and stereochemistry were elucidated by chemical and spectral evidence, especially 2D NMR spectroscopic techniques. Pharmacological activities on anti-inflammation have been tested.

Keywords:

• Gnetaceae
• Gnetupendin D
• Stilbenoid

Acknowledgements

This research program was supported by the National Natural Science Foundation of China (NSFC. # 30,070,889). The authors thank the Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College for the measurement of UV, IR, NMR and EIMS spectra, and thank Dr K.H. Wei, National Center of Biomedical Analysis, Academy of Military Medical Sciences, for measurement of FAB-MS spectra; the authors also thank Professor G.F. Cheng for biological testing.