Two new cyclolanostanol glycosides from the aerial parts of Cimicifuga foetida

Abstract

Two new cyclolanostanol glycosides, cimifoetiside IV (1) and cimifoetiside V (2) and two known compounds have been isolated from the aerial part of Cimicifuga foetida L. On the basis of spectral and chemical evidences, the structures of 1 and 2 were elucidated to be 25-O-acetylcimigenol-3-O-β-d-glucopyranosyl-(1″→2′)-β-d-xylopyranoside (1) and cimigenol-3-O-β-d-glucopyranosyl-(1′″→2″)-β-d-glucopyranosyl-(1″→2′)-β-d-xylopyranoside (2). The known compounds were identified as 25-O-acetylcimigenol-3-O-β-d-glucopyranosyl-(1→3)-β-d-xylopyranoside (3) and 23-O-acetylshengmanol-3-O-β-d-glucopyranosyl-(1→3)-β-d-xylopyranoside (4).

Keywords:

• Cimicifuga foetida
• Ranunculaceae
• Cimifoetiside IV
• Cimifoetiside V

Acknowledgements

The authors are grateful to Dr Guangzhong Tu and Miss Dongge An, Beijing Institute of Microchemistry Research, for NMR spectral measurements; to Dr Kaihua Wei, Academy of Military Medical Sciences, Beijing Center of Biomedical Analysis for the FAB mass spectral measurements; and to Mr H. T. Song and Ms Qi Zhang of our Institute for the IR and optical rotation spectral measurements.