Abstract
Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12β,13α-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound.
Acknowledgements
We thank the National Outstanding Youth Foundation by NSF of China (39925040) and Trans-Century Training Program Foundation for the Talents by the Ministry of Education for financial support.