Cerebroside Analogues from Marine-Derived Fungus Aspergillus flavipes

Abstract

From the mycelium of the marine-derived fungus Aspergillus flavipes, isolated from the sea anemone Anthopleura xanthogrammica, two new cerebroside analogues, namely flavicerebrosides A (1): [(2S,2′R,3R,4E,8E)-N-2′-hydroxyoctadecanoyl-1-O-β-d-galactopyranosyl-9-methyl-4,8-sphingadienine], and B (2): [(2S,2′R,3R,3′E,4E,8E)-N-2′-hydroxy-3′-octadecenoyl-1-O-β-d-galactopyranosyl-9-methyl-4,8-sphingadienine], together with two known glycosphingolipids cerebrosides D (3) and C (4), were isolated. Their structures were identified by means of extensive spectroscopic analysis (IR, UV, 2D NMR, MS, CD) and chemical degradation. All four compounds showed cytotoxic activity against the KB cell line.

Keywords:

• Fungus
• Aspergillus flavipes
• Flavicerebrosides A and B

Acknowledgements

This work was supported by a grant from the National Natural Science Foundation of China (NNSFC, No. 40176038), which is gratefully acknowledged.