A novel polyhydroxyl sterol from Asterina pectinifera

Abstract

A novel polyhydroxyl sterol (1) along with one known polyhydroxyl sterol (2), and two known monoglycosides, asterosaponin P₁ (3) and its desulfated monoglycoside (4), have been isolated from the whole bodies of a common Pacific starfish Asterina pectinifera. The structure of the new polyhydroxyl sterol was determined as 15β,16β-isopropylidenedioxy-5α-cholestane-3β,4β,6α,7α,8,26-hexaol by spectroscopic methods, including FABMS, HR-FABMS, 1D and 2D NMR techniques.

Keywords:

• Asterina pectinifera
• Starfish
• Polyhydroxyl sterol

Acknowledgements

We thank the staff of the analytical group of the Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College for recording the HFABMS and NMR spectra. This work was financially supported by the National “863” Program of P. R. China (Grant No. 2001AA620403).

Notes

Tel: [phone], Fax: [phone], Email: [email protected]

Additional information

Notes on contributors

Jian-Gong Shi

Tel: [phone], Fax: [phone], Email: [email protected]