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Journal of Asian Natural Products Research Volume 7, 2005 - Issue 6
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Original Articles

Microbial transformation of fraxinellone by Aspergillus niger

Note

R.-L. Yang Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China
,
T.-L. Jia Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China
&
R.-Q. Zhang Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, ChinaCorrespondence[email protected]
Pages 843-845 | Received 30 Jul 2003, Accepted 14 Nov 2003, Published online: 21 Aug 2006
 
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Abstract

Microbial transformation of fraxinellone (1) by Aspergillus niger (AS 3.421) has been carried out. Two converted products, dasycarpol (2) and a new compound fraxinigerllone (3) were obtained. Their structures have been identified on the basis of spectroscopic methods. Dasycarpol shows moderate inhibitory activity on lung cancer cell line A549.

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