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Journal of Asian Natural Products Research Volume 8, 2006 - Issue 8
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Original Articles

Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice

X.-W. Yang State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing, 100083, ChinaCorrespondence[email protected]
,
H. Zhang State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing, 100083, China
,
M. Li Laboratory of Pharmaceutical Science, Department of Biological Science and Biotechnology, Tsinghua University, Beijing, 100084, China
,
L.-J. Du Laboratory of Pharmaceutical Science, Department of Biological Science and Biotechnology, Tsinghua University, Beijing, 100084, China
,
Z. Yang The Administrative Centre for China's Agenda 21, Ministry of Science and Technology, Beijing, 100089, China
&
S.-Y. Xiao The Administrative Centre for China's Agenda 21, Ministry of Science and Technology, Beijing, 100089, China
Pages 697-703 | Received 12 Jan 2004, Accepted 19 May 2004, Published online: 06 Dec 2006
 
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Abstract

Six alkaloids (1–6) have been isolated from the fruits of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang, two of which are new compounds, identified as 2-undecyl-4(1H)-quinolone (4) and 1-methyl-2-undecanone-10′-4(1H)-quinolone (5); the known compounds were identified as rutaecarpine (1), evodiamine (2), 1-methyl-2-undecyl-4(1H)-quinoline (3) and 2-undecanone-10′-4(1H)-quinolone (6). Compounds 1–5 were evaluated for their acute toxicity.

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