Abstract
A new lignan glycoside, named 1,5-dihydroxypinoresinol-4′-O-β-d-glucopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-β-d-glucopyranoside (2), fraxiresinol-4′-O-β-d-glucopyranoside (3), ( − )-olivil-4″-O-β-d-glucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-β-d-glucopyranoside, syringin, costunolide-15-O-β-d-glucopyranoside, chlorogenic acid, aloe-emodin-8-O-β-d-glucopyranoside (5), rhein-8-O-β-d-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, β-costic acid, reynosin, arbusculin A, α-cyclocostunolide, β-cyclocostunolide, santamarine and magnolialide. Three anthraquinones (5–7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
Acknowledgements
The authors gratefully acknowledge the support of this work by the National Natural Science Foundation (30100229) and the Technology Development Fund of Shanghai, China (01QB14051).