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Original Articles

A new sesquiterpene ester inhibiting no production from the fruits of Celastrus orbiculatus

, , , , , & show all
Pages 739-742 | Received 09 Mar 2004, Accepted 24 May 2004, Published online: 06 Dec 2006
 

Abstract

A new β-dihydroagarofuran sesquiterpene ester, 1β,2β,6α, 13-tetraacetoxy-9α-cinnamoyloxy-β-dihydroagarofuran (1), and the known compound 1β,6α,13-triacetoxy-9α-benzoyloxy-β-dihydroagarofuran (2), have been isolated from the fruits of Celastrus orbiculatus Thunb. Their structures have been elucidated on the basis of spectroscopic methods. Compound 1 shows moderate activity of inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with an IC50 of 55.4 μM.

Acknowledgements

Special thanks are due to the Analytical Center, Shenyang Pharmaceutical University, for recording UV, MS and NMR spectra. We are also thankful to Professor Yunzheng Guo for plant identification (Shenyang Pharmaceutical University, China).

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