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Journal of Asian Natural Products Research Volume 9, 2007 - Issue 2
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Original Articles

Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis

Z.-C. Zhang Zhejiang Hospital 12 Ling Yin Road, Hangzhou, Zhejiang Province, 310013, China
,
S.-J. Li Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
,
Y.-Z. Yang Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, ChinaCorrespondence[email protected]
,
R.-Z. Chen Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
,
J.-B. Ge Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
&
H.-Z. Chen Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
Pages 145-151 | Received 09 Mar 2004, Accepted 26 May 2004, Published online: 02 Apr 2007
 
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Abstract

Astragaloside is the major component of Astragalus membranaceus, one of the Chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities. We have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus B3 (CVB3)-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay and the latter determined by using a focused microarray. Results showed that cardiomyocyte apoptosis and expression of various apoptosis associated genes are inhibited after treatment with astragaloside. The anti-apoptotic activity of astragaloside may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.

Acknowledgements

This work was supported by a grant from the National Natural Science Foundation of China (no. 30271665).

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