Triterpenoid glycoside from Cimicifuga racemosa

Abstract

One new triterpene glycoside, cimiracemoside (I), and 14 known triterpene glycosides have been isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). On the basis of spectral and chemical evidence, the structure of the new compound was elucidated to be 12β-acetoxycimigenol-3-O-β-d-xylopranoside (1), and the known compounds were identified to be 25—acetylcimigenol xyloside (2), cimigenol-3-O-β-d-xylopyranoside (3), acetin (4), 27-deoxyacetin (5), cimicifugoside H-1 (6), 23-O-acetylshengmanol 3-O-β-d-xylopranoside (7), foetidinol-3-O-β-xyloside (8), cimicifugoside H-2 (9), 25-O-methylcimigenol xyloside (10), 21-hydroxycimigenol-3-O-β-d-xylopyranoside (11), 24-epi-7,8—didehydrocimigenol-3-xyloside (12), cimidahurinine (13), cimidahurine (14) and cimifugin (15). The compounds 1–5, 14, and 15 showed weak antibacterial activities in the agar diffusion assay.

Keywords:

• Cimicifuga racemosa
• Ranunculaceae
• Cimiracemoside I
• Antibacterial activity

Acknowledgements

The authors wish to express thanks to members of the analytical group for the spectroscopic measures, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany.