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Journal of Asian Natural Products Research Volume 8, 2006 - Issue 4
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Original Articles

Relationship between the antibacterial and immunological activities of houttuyfonate homologues and their surface activities

X.-L. Ye School of Life Science, Southwest China Normal University, Chongqing, 400715, China
,
X.-G. Li Chemistry Institute of Pharmaceutical Resources, Southwest Agricultural University, Chongqing, 400716, ChinaCorrespondence[email protected]
,
L.-J. Yuan Inspection Centre for Agri-food Quality and Safety, Southwest Agricultural University, Chongqing, 400716, China
&
H.-M. He Chemistry Institute of Pharmaceutical Resources, Southwest Agricultural University, Chongqing, 400716, China
Pages 327-334 | Received 17 Jun 2004, Accepted 10 Oct 2004, Published online: 04 Sep 2006
 
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Abstract

Based on the microbial model (Staphylococcus aureus and Bacillus subtilis) and the experiment of mouse carbon granular clearance, the relationship between antibacterial and immunological activities of houttuyfonate (HOU) homologues and their surface activities were studied. The results showed that with elongating the carbon chain of HOU homologues, the surface activities and bacteriostasis and immunological activities would be increased. It is suggested that the pharmacological effect of HOU homologues could be realized by the hydrophobic interaction between HOU homologues and membrane proteins of bacteria and cell.

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