Coumarins from Coriaria nepalensis

Abstract

Two new coumarins (1) and (2), along with seven known coumarins 3–9, were isolated from the leaves and stems of Coriaria nepalensis Wall. The two new compounds were established as 7-hydroxy-6-methoxy-3,8-bis(3-methyl-2-butenyl) coumarin (1) and 7-hydroxy-6-methoxy-3-(3-methyl-2-butenyl) coumarin (2), on the basis of 1D and 2D NMR techniques. The known compounds 3, 6–9 were isolated from this plant for the first time.

Keywords:

• Coriaria nepalensis
• Coriariaceae
• Coumarins
• 7-Hydroxy-6-methoxy-3,8-bis(3-methyl-2-butenyl) coumarin
• 7-Hydroxy-6-methoxy-3-(3-methyl-2-butenyl) coumarin

Acknowledgements

This project was supported by grants from the National Natural Sciences Foundation of China (No. 30200349), the Natural Sciences Foundation of Yunnan Province (No. 2002C0017Q), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2003RC07, awarded to S.-H.L.).