Antioxidant phenolic glucosides from Gentiana piasezkii

Abstract

An extract of Gentiana piasezkii afforded a new arbutin derivative 6′-O-vanilloylarbutin (1) and a new flavone-C-glucoside 7-O-feruloylorientin (2), together with four known flavonoids lutonarin (3), saponarin (4), isoorient (5) and luteolin (6). Their structures were established based on spectroscopic methods including 2D NMR (COSY and gHMBC) techniques. Compounds 1, 2, 5 and 6 were evaluated for the antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay system.

Keywords:

• Gentiana piasezkii
• Gentianaceae
• Arbutin derivative
• Flavone glucosides
• Antioxidant activity

Acknowledgements

The authors are greatly indebted to Professor Ji Ma (Faculty of Pharmacy, First Military Medical University of PLA, Guangzhou, P.R. China) for her help in identification of the plant material. This work was supported by the National Natural Science Foundation of China (NSFC 20021001, 20372029 and 20475057).