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Journal of Asian Natural Products Research Volume 8, 2006 - Issue 1-2
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Original Articles

Isolation, structure determination and biological activity of a new glutarimide antibiotic, S632A3

Chun-Lei Cheng Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of China
,
Qiong-Yan Liu Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of China
,
Li-Hui Chen Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of China
,
Wen-Zao Jin Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of China
,
Shu-Yi Si Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of China
&
Dian-Dong Li Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, 100050, People's Republic of ChinaCorrespondence[email protected]
Pages 55-60 | Received 28 Apr 2005, Accepted 25 Jul 2005, Published online: 25 Jan 2007
 
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Abstract

A new antibiotic, S632A3, was isolated from a cultured broth of Streptomyces hygroscopicus S632. It was purified by column chromatography on silica gel, Sephadex LH-20 and HPLC. Structural studies by analysis of 1H NMR and 13C NMR, MS, UV and IR spectra in comparison with those of S632A2 clarified that S632A3 is an isomer of 9-methylstreptimidone. In addition, this antibiotic showed potent biological activity including differentiation induction effects on HL-60 cell and antitumour activity in vivo.

Acknowledgements

We thank the Major State Basic Research Development Program (No. 2000057010), the New Drugs Screen Technology Platform Program Foundation (2002AA22343D) and the National Natural Science Foundation of China (No. 30472042) for financial support.

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