Yuexiandajisu D, a novel 18-nor-rosane-type dimeric diterpenoid from Euphorbiaebracteolata Hayata

Abstract

Yuexiandajisu D, a novel 18-nor-rosane-type dimeric diterpenoid, was isolated from the roots of Euphorbia ebracteolata Hayata. Its structure was elucidated as 6,3′:7,2′-diepoxy-di-2,3-dihydroxy-18-nor-ros-1(10),2,4,15-tetraene by spectroscopic techniques (HSQC, HMBC, DQF-COSY, TOCSY, NOESY) and chemical methods. Yuexiandajisu D showed moderate cytotoxic activity against cancer cell lines on HCT-8 and Bel-7402, with IC₅₀ values of 2.66 and 3.76 μM, respectively.

Keywords:

• Euphorbiaceae
• Euphorbia ebracteolata
• Yuexiandajisu D
• 18-Nor-rosane diterpenoid
• Dimeric diterpenoid

Acknowledgements

We are grateful to Dr. Qiu Shengxiang, Professor of Washington University, for the measurement of part of the NMR data, the members of MS measurement centre of the school of China Materia Medica, China Pharmaceutical University, Nanjing, China. This work was supported by both a grant from the State Ministry of Education (No. 02118), and a grant for outstanding scholar from Jangsu Province Government, awarded to Dr Bo-yang Yu.