Jacaranone glycosides from Senecio scandens

Abstract

Bioassay-guided fractionation of the ethanol extract of Senecio scandens led to the isolation of four new compounds 1–4. These compounds were obtained as tautomeric mixture of α/β epimers, but their structures were confirmed unambiguously by 1D and 2D NMR spectra and LC NMR technology. ¹H NMR spectra of pure 1α and 1β were furnished by HPLC NMR technology. Compounds 1–4 exhibited moderate cytotoxicities against five tumor cell lines.

Keywords:

• Senecio scandens
• Benzoquinone
• Jacaranone glycosides
• Cytotoxicity

Acknowledgements

The authors are thankful to the Beijing Municipal Science & Technology Commission of China for the financial support. We also thank Mr Hongyan Liu for the cytotoxicity assay and Ms Xiaohua Ma for energy minimisation calculations.