Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines

Abstract

A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various ¹H NMR and ¹³C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2′, 4′, 6′-octatriendioic acid esterified on the 4β-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines.

Keywords:

• Harzianum B
• Hypocrea sp
• Cytotoxicity
• Tumor cell lines

Acknowledgements

This work was supported in part by a grant from Korea Research Institute of Bioscience & Biotechnology Research Initiative Program, and a research grant (PF0320701-00) from Plant diversity Research Center of 21st Frontier Research Program funded by the Korean Ministry of Science & Technology, and BK21 Fellowship from the Ministry of Education & Human Resources Development of Korea.