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Journal of Asian Natural Products Research Volume 8, 2006 - Issue 6
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Original Articles

A new sesquiterpene lactone glucoside with inhibitory effect on K562 cells from Ixeris sonchifolia (Bge) Hance

W.-F. He School of Pharmacy, Wenzhou Medical College, Wenzhou, 325035, China
,
B.-B. Xu School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
J.-C. Pan School of Pharmacy, Wenzhou Medical College, Wenzhou, 325035, China
,
J.-C. Lu School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
S.-J. Song School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China
&
S.-X. Xu School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]
Pages 481-484 | Received 08 Oct 2004, Accepted 08 Dec 2005, Published online: 17 Dec 2010
 
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Abstract

A new minor sesquiterpene lactone glucoside, ixerin ZA (1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6′-(p-metheoxyphenylacetyl)]-β-glucopyranoside on the basis of spectroscopic and chemical evidence. Compound 1 exhibited an inhibitory effect on K562 cells.

Acknowledgements

We are grateful for the use of HRFAB-MS facilities at the Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.

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