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Journal of Asian Natural Products Research Volume 9, 2007 - Issue 3
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Original Articles

Two eudesmane sesquiterpenes from Laggera pterodonta

Y.-B. Liu R & D Centre of Zhongxin Pharmaceuticals Group Co. Ltd., Tianjin, 300457, China
,
W. Jia The School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200030, China
,
Z. Yao Department of Immunology, Tianjin Medical University, Tianjin, 300070, China
,
Q. Pan Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, 770-8505, Japan
,
Y. Takaishi The School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China
&
H.-Q. Duan R & D Centre of Zhongxin Pharmaceuticals Group Co. Ltd., Tianjin, 300457, ChinaCorrespondence[email protected]
Pages 233-237 | Received 27 Sep 2006, Accepted 20 Dec 2006, Published online: 04 Mar 2011
 
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Abstract

Two new eudesmane sesquiterpenes, 2α-hydroxy pterodontic acid (1) and pterodolide [3α-(2-methyl-2,3-epoxy)-butyric-4α-acetoxy-8β-ethoxy eudesma-7(11)-en-8α,12-olide (2), along with five known compounds (3–7) were isolated from the aerial parts of Laggera pterodonta. Their structures were elucidated on the basis of spectroscopic methods. The immunosuppressive activity of the isolated compounds was investigated.

Acknowledgements

The project was sponsored by the Scientific Research Foundation of Tianjin Medical University.

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