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Original Articles

A new nonadride derivative from mangrove fungus (strain No. k38)

, , , &
Pages 285-291 | Received 27 Sep 2005, Accepted 22 Feb 2006, Published online: 04 Mar 2011
 

Abstract

A new nonadride derivative, ( − )-1-hydroxybyssochlamic acid (1) and the known ( − )-byssochlamic acid (2) were isolated from mangrove fungus (strain No. k38) collected from the South China Sea coast. The structure and relative configuration of 1 were elucidated by spectral data and X-ray diffraction analysis. Primary bioassays showed that 2 had medium cytotoxic activity against HEp-2 and HepG2 Cells, and 1 exhibited weak activity.

Acknowledgements

We wish to acknowledge financial support from the National Natural Science Foundation of China (20072058), the 863 Foundation of China (2003AA624010), the Natural Science Foundation of Guangdong Province, China (021732), and the Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China.

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