27-Nor-triterpenoid glycosides from the barks of Zygophyllum fabago L.

Abstract

From the bark of Zygophyllum fabago L., a new 27-nor-triterpenoid glycoside, 3-O-β-d-glucopyranosyl-pyrocincholate (1), together with five known compounds, 3-O-6-deoxy-β-d-glucopyranosyl-pyrocincholate (2), quinovic acid (3), 3-O-6-deoxy-β-d-glucopyranosyl-quinovic acid (4), 3-O-β-d-glucopyranosyl- quinovic acid (5) and 3-O-6-deoxy-β-d-glucopyranosyl-cincholic acid (6), were isolated and their structures elucidated on the basis of spectroscopic data. Compounds 1, 2 and 3 showed some anti-tumour activities by MTT assay.

Keywords:

• Zygophyllum fabago L
• Zygophyllaceae
• 27-Nor-triterpenoid glycoside
• 3-O-β-d-Glucopyranosyl-pyrocincholate
• Anti-tumour activity

Acknowledgements

The authors express their gratitude to Professor Pu-Zhu Cong for his helpful suggestions for the interpretation of mass spectra, to Mr Qiu-Ping Ding for obtaining the 400 MHz one- and two-dimensional NMR data, and to Mr Jiu-Ming He for recording the ESI-MS and HRFAB-MS.