Resorcinol derivatives from Ardisia maculosa

Abstract

Besides a series of known sterols and triterpenoids, a new resorcinol (1) and a known resorcinol (2) have been isolated from ethanol extract of Ardisia maculosa for the first time. The structures of these resorcinol derivatives were elucidated as 2-methyl-5-(Z-heptadec-8-enyl) resorcinol and 5-Z-heptadec-8-enyl) resorcinol by HRESI-MS, NMR (¹H, ¹³C, HSQC, HMBC) experiments. In our in vitro assay, compounds 1 and 2 showed no antimicrobial activities, however, compound 2 exhibited cytotoxity activity against human cancer cell line with GI₅₀ value of 2.14 × 10^− 4 mmol/ml.

Keywords:

• Antimicrobial activity
• Ardisia maculosa
• Cytotoxity
• Resorcinol