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Journal of Asian Natural Products Research Volume 9, 2007 - Issue 7
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Original Articles

Two new lanostanoids from Ganoderma resinaceum

Xue-Mei Niu School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, 650204, Yunnan, China
,
Sheng-Hong Li State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, 650204, Yunnan, China
,
Wei-Lie Xiao State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, 650204, Yunnan, China
,
Han-Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, 650204, Yunnan, China
&
Chun-Tao Che School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, ChinaCorrespondence[email protected]
Pages 659-664 | Received 24 May 2006, Accepted 07 Aug 2006, Published online: 04 Mar 2011
 
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Abstract

Two new lanostane triterpenoids, 3-epipachymic acid (3α-acetoxy-16α-hydroxy-24-methylene-5α-lanost-8-en-21-oic acid, 1) and 3α-(3-hydroxy-5-methoxy-3-methyl-1,5-dioxopentyloxy)-24-methylene-5α-lanost-8-en-21-oic acid (2), together with a known compound, 3-oxo-5α-lanosta-8,24-dien-21-oic acid (3), were isolated from the fruiting body of Ganoderma resinaceum. The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC50 value of 2.5 μg/ml in Hep-2 cell line.

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